This session covers the newest in early-onset and late-onset sepsis treatment. Speakers will cover biomarkers for diagnosis, risk stratification, and therapy duration. Decision-making on the initiation or withholding of antibiotics will be examined through case studies. Speakers will also bring forward infection prediction tools and point-of-care diagnostics. Guidelines to avoid antimicrobial resistance will be highlighted. Critical for clinicians who want to optimize sepsis outcomes and prevent overuse.